化学合成；生命科学。
化学合成；生命科学；医药中间体；生化试剂
合成路线 1（1. 合成：7517-19-3）
产率：100%
合成条件：Stage #1: for 1 h; Cooling with ice Stage #2: at 20 - 66℃; for 6.50 h;
实验步骤：在冰浴下，向100ml圆底烧瓶中加入60ml甲醇，然后通过恒压滴液漏斗（顶部带有干燥管）缓慢加入4ml SOCl2，并用NaOH溶液吸收废气。 搅拌1小时后，加入8mmol L-亮氨酸并在室温下搅拌30分钟，然后在66℃下回流6小时。 通过TLC跟踪反应直至原料消失，用2％茚三酮在乙醇中的溶液作为显色剂。 蒸除溶剂，得到L-亮氨酸甲酯盐酸盐。 产量：100％。
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