化学合成。
化学合成
合成路线 1（1. 合成：40191-32-0）
产率：100%
合成条件：With thionyl chloride In toluene at 80℃; for 1.50 h;
实验步骤：例5; 四氢吡喃-4-羧酸氯化物的合成在玻璃容器中，内容积为50ml，装有搅拌装置，温度计和回流冷凝器的容器中加入6.85g（52.6mmol）四氢吡喃-4-羧酸 酸，9.79g（82.3mmol）亚硫酰氯和10ml甲苯，在搅拌下使混合物在80℃反应1.5小时。 反应完成后，将反应混合物减压浓缩，得到7.81g（分离产率; 100％）四氢吡喃-4-羧酰氯，为淡褐色液体。四氢吡喃-4-羧酸氯化物的物理性质如下 符合1 H-NMR（CDCl 3，δ（ppm））; 1.79至1.93（2H，m），1.99至2.06（2H，m），2.91至3.00（1H，m），3.40至3.49（2H，m），3.97至4.03（2H，m）CI-MS（m / mE）; 131（M + 1）
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