化学合成；作为利尿药（碳酸酐酶抑制剂），抑制肾小管上皮细胞碳酸酐酶，增加HCO3-、Na+、K+排出，用于治疗青光眼、轻度心脏性水肿；还可抑制房水分泌降低眼压。
医药; 化学合成
路线1：PEG-SANM纳米复合物催化还原
- 步骤：将底物（1mmol）和PEG-SANM纳米复合物（8mg）在甲醇（2mL）中混合，室温搅拌反应（TLC监测），反应完成后滤除催化剂，减压蒸发溶剂，硅胶柱色谱纯化得产物。
- 条件：甲醇溶剂，20℃，0.01h。
- 收率：96%。
- 参考文献：[1] Bulletin of the Chemical Society of Japan, 2000, vol.73, #12, p.2775-2778；[2] Synthetic Communications, 2001, vol.31, #6, p.905-909；[3] Phosphorus, Sulfur and Silicon and the Related Elements, 2016, vol.191, #6, p.944-951；[4] RSC Advances, 2016, vol.6, #28, p.23564-23570；[5] Journal of the Chinese Chemical Society, 2008, vol.55, #5, p.943-946；[6] Tetrahedron Letters, 2001, vol.42, #38, p.6771-6774
路线2：硼氢化钠还原
- 步骤：苯甲醛衍生物（1mmol）的甲醇（15mL）溶液中加入硼氢化钠（2mmol），室温搅拌1小时，后处理得产物。
- 条件：甲醇溶剂，20℃，1h。
- 收率：100%。
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