21252-69-7 1-辛基咪唑

常温运输。危险性类别：眼部刺激 类别2、经皮刺激 类别2、特异性靶器官毒性-一次接触，类别3；危险描述：H315（造成皮肤刺激）、H319（造成严重眼刺激）、H335（可能引起呼吸道刺激）；危险标志：GHS07；WGK Germany:3；存储类别:10 - 可燃性液体；危险性防范说明：P261（避免吸入粉尘/烟雾/气体/烟雾/蒸气/喷雾）、P305 + P351 + P338（如进入眼睛，用水小心冲洗几分钟；如戴隐形眼镜并可方便取出，取出隐形眼镜，继续冲洗）。

化学合成

化学合成

合成路线 1（1. 合成：21252-69-7）

• 产率：89%
• 合成条件：Stage #1: With sodium hydroxide In dimethyl sulfoxide at 90℃; for 2 h; Stage #2: at 20 - 65℃; for 19 h;
• 实验步骤：将咪唑（1.36g，20.0mmol）和氢氧化钠（0.80g，20.0mmol）在DMSO中的混合物加热至90℃并保持2小时，然后冷却至室温。向混合物中滴加1-溴辛烷（3.46g，19.0mmol）的DMSO溶液。在室温下搅拌3小时后，在不断搅拌下将混合物缓慢加热至65℃保持16小时。将得到的溶液与水混合，用乙醚萃取产物4次。合并乙醚相，用硫酸钠干燥。真空除去乙醚，得到中间体（9），为黄色液体（2.89g，89％）。
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