133343-34-7 乳胞素

名称和标识

中文名: 乳胞素
英文名: lactacystin
CAS号: 133343-34-7
分子式: C15H24N2O7S
分子量: 376.43
中文别名: (+)-LACTACYSTIN; 乳酸胱氨酸; 蛋白酶体抑制剂
英文别名: (+)-Lactacystin; N-Acetyl-S-((2R,3S,4R)-3-hydroxy-2-((S)-1-hydroxy-2-methylpropyl)-4-methyl-5-oxopyrrolidine-2-carbonyl)-L-cysteine; (2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBOXY-N-ACETYL-L-CYSTEINE THIOESTER; 3S-HYDROXY-2R-(1-HYDROXY-2-METHYLPROPYL)-4R-METHYL-5-OXO-2-PYRROLIDINECARBOXYLATE-N-ACETYL-L-CYSTEINE; LACTACYSTIN (NATIVE); LACTACYSTIN, STREPTOMYCES SP; LACTACYSTIN, SYNTHETIC; N-ACETYL-S-[(2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBONYL]-L-CYSTEINE; N-Acetyl-S-({(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)-L-cysteine; N-Acetyl-S-({(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinyl}carbonyl)-L-cysteine

安全说明

运输方式为冰袋运输。危险性质：非危险化学品。WGK Germany:3，存储类别:11 - 可燃固体。

用途与制备

化学合成；生物活性研究（作为抗生素，抑制20S蛋白酶体（IC50 4.8 μM）及溶酶体酶组织蛋白酶A，抑制细胞生长并诱导神经突增生）；体内研究（通过微量注射（2 µg）在小鼠中诱导帕金森病样运动表型）。

医药

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