89-58-7 2,5-二甲基硝基苯

危险品运输编号1665，RTECS号ZE4686600，TSCA listed，危险等级6.1，包装类别II，海关编码29042090，毒性LD50 orl-rat: 2440 mg/kg。

用于有机合成；具有急性毒性（口服-大鼠LD50: 2440 毫克/公斤）；与氧化剂混合可爆；明火可燃，受热分解有毒氮氧化物气体；库房通风低温干燥，与食品原料、还原剂分开储运；灭火剂为泡沫、雾状水、二氧化碳、干粉、砂土。

有机合成

合成路线 1（1. 合成：89-58-7）

产率：86.4% 合成条件：With nitric acid In acetic anhydride at 20℃; for 10 h; 实验步骤：在50mL双颈圆底烧瓶中，加入沸石HBEA-25（Si/Al=25，0.11g）、邻二甲苯（0.60mL，5mmol）、硝酸（65%，0.68mL，10mmol）和乙酸酐（5.0mL），室温搅拌反应10小时。反应结束后过滤除去沸石，滤液用NaHCO₃（3×10mL）和水（3×10mL）洗涤，有机相经无水硫酸钠干燥、过滤，得稻草黄色液体残余物。通过气相色谱内标法估算产物异构体分布和产率，柱色谱纯化后鉴定。 参考文献：[1] Russian Journal of Organic Chemistry, 1993, vol.29, #3.2, p.457-466；[2] Zhurnal Organicheskoi Khimii, 1993, vol.29, #3, p.546-558；[3] Tetrahedron Letters, 1996, vol.37, #4, p.513-516；[4] Journal of Fluorine Chemistry, 2008, vol.129, #6, p.524-528；[5] Organic Letters, 2018, vol.20, #11, p.3197-3201；[6] Green Chemistry, 2015, vol.17, #6, p.3446-3451；[7] Journal of Fluorine Chemistry, 1990, vol.46, #3, p.507-513；[8] Synthetic Communications, 2005, vol.35, #17, p.2237-2241；[9] Journal of Organic Chemistry, 2006, vol.71, #10, p.3952-3958；[10] Journal of Organic Chemistry, 1981, vol.46, #17, p.3533-3537；[11] Russian Journal of Organic Chemistry, 2005, vol.41, #10, p.1493-1495；[12] Chemische Berichte, 1997, vol.130, #5, p.581-584；[13] Bulletin of the Korean Chemical Society, 2013, vol.34, #11, p.3485-3487；[14] Chemistry Letters, 2014, vol.43, #6, p.817-819；[15] Australian Journal of Chemistry, 2015, vol.68, #7, p.1122-1128；[16] Tetrahedron Letters, 2004, vol.45, #15, p.3137-3139；[17] RSC Advances, 2013, vol.3, #3, p.691-694；[18] Journal of Organic Chemistry, 1989, vol.54, #7, p.1692-1702；[19] Journal of Organic Chemistry, 1981, vol.46, #17, p.3533-3537；[20] Journal of the American Chemical Society, 1992, vol.114, #5, p.1756-1770；[21] Journal of the American Chemical Society, 1948, vol.70, p.3787；[22] Journal fuer Praktische Chemie (Leipzig), 1935, vol.<2>142, p.153,166；[23] Justus Liebigs Annalen der Chemie, 1875, vol.176, p.55；[24] Journal of the American Chemical Society, 1953, vol.75, p.4307,4310；[25] Industrial and Engineering Chemistry, 1950, vol.42, p.352；[26] Recueil des Travaux Chimiques des Pays-Bas, 1954, vol.73, p.39,47；[27] Canadian Journal of Chemistry, 1974, vol.52, p.3960-3970；[28] Australian Journal of Chemistry, 1973, vol.26, p.775-783；[29] Journal of Organic Chemistry, 1961, vol.26, p.919-923；[30] Magnetic Resonance in Chemistry, 1985, vol.23, #7, p.597-604；[31] Journal of the Chemical Society - Perkin Transactions 2, 1995, #7, p.1541-1550；[32] Journal of the Chemical Society - Perkin Transactions 1, 1996, #19, p.2385-2389；[33] Chemical Communications, 1997, #6, p.613-614；[34] Molecules, 2005, vol.10, #8, p.978-989；[35] Advanced Synthesis and Catalysis, 2003, vol.345, #12, p.1329-1333；[36] Catalysis Communications, 2011, vol.14, #1, p.42-47；[37] Tetrahedron Letters, 2012, vol.53, #50, p.6782-6785,4；[38] Catalysis Communications, 2014, vol.49, p.82-86