106261-64-7 4-(4-甲基哌嗪甲基)苯甲酰氯二盐酸盐

名称和标识

中文名: 4-(4-甲基哌嗪甲基)苯甲酰氯二盐酸盐
英文名: 4-[(4-Methylpiperazin-1-yl)methyl]benzoyl chloride dihydrochloride
CAS号: 106261-64-7
分子式: C13H19Cl3N2O
分子量: 325.66
中文别名: 伊玛酰氯; 伊马酰氯; 伊马替尼中间体5; 伊马替尼杂质17
英文别名: 4-(4-Methylpiperizinomethyl)benzoylchloride 2HCl; 4-(4-Methylpiperizinomethyl)benzoylchloride dihydrochloride; 4-(4-METHYLPIPERAZINYLMETHYL)BENZOYL CHLORIDE DIHYDROCHLORIDE; 4-[(4-Methyl-1-piperazinyl)methyl]benzoyl chloride dihydrochloride; 4-[(4-Methyl-1-piperazinyl)Methyl]benzoyl chloride; Benzoyl chloride,4-[(4-Methyl-1-piperazinyl)Methyl]-, hydrochloride (1:2); 4‐[(4‐Methyl‐1‐piperazinyl)‐methyl]‐benzoyl chloride hydrochloride; 4-(4-Methylpiperazinylmethyl)benzoyl chloride DiHCl; Imatinib Impurity 17; 4-(4-Methylpiperazinomethyl)benzoyl chloride dihydrochloride; 1-[4-(Chlorocarbonyl)benzyl]-4-methylpiperazinediium dichloride

安全说明

运输信息：冰袋运输。危险描述：非危险化学品。

用途与制备

化学合成；用作医药合成中间体

医药

路线1：

步骤: 将伊马酸1g(5g，0.021mol，安耐吉化学)投入100mL三口瓶，加入二氯亚砜(35mL)和催化剂N,N-二甲基甲酰胺(0.3mL)，加热回流反应22小时，降至室温，抽滤，正己烷洗涤(10mL×2)，45～50℃真空干燥2小时，得白色固体状的4-(4-甲基哌嗪甲基)苯甲酰氯二盐酸盐(1h)5.1g。
收率: 95％

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