312-94-7 2-三氟甲基苯甲酰氯

危险品运输编号UN 3265 8/PG 2，危险等级8，包装类别II，海关编码29163990，存储类别8A - 可燃，腐蚀性物质，危险性类别皮肤腐蚀类别1B，有腐蚀性和催泪性，WGK Germany:3，F:19-21，毒性:skn-rbt 500 mg/24H MOD FCTXAV 13,681,75。

化学合成，杀菌剂氟酰胺的中间体。

医药; 农药

路线1：

• 步骤: 将草酰氯加入搅拌的2-三氟甲基-苯甲酸的二氯甲烷溶液中，加入四滴DMF，室温搅拌1小时，减压浓缩得到产品。
• 条件: 草酰氯（36.72mg，0.29mmol）、2-三氟甲基-苯甲酸（50mg，0.26mmol）、二氯甲烷（3mL）、室温（20℃）、1小时。
• 收率: 100%（95.6mg）
• 参考文献: [1] Patent: US2010/160323, 2010, A1. Location in patent: Page/Page column 28 [2] Journal of the American Chemical Society, 1947, vol. 69, p. 2352 [3] Bulletin de la Societe Chimique de France, 1962, p. 587 - 593 [4] Journal of Medicinal Chemistry, 1982, vol. 25, # 2, p. 145 - 152 [5] Journal of Medicinal Chemistry, 1999, vol. 42, # 6, p. 981 - 991 [6] Pesticide Science, 1994, vol. 41, # 2, p. 139 - 148 [7] Journal of Medicinal Chemistry, 2003, vol. 46, # 23, p. 4895 - 4903 [8] Journal of Medicinal Chemistry, 2007, vol. 50, # 6, p. 1365 - 1379 [9] Journal of Medicinal Chemistry, 2001, vol. 44, # 3, p. 362 - 371 [10] Patent: US2006/14777, 2006, A1. Location in patent: Page/Page column 22 [11] Patent: US5536718, 1996, A [12] Patent: US5753648, 1998, A [13] Patent: US5700796, 1997, A [14] Patent: WO2006/27795, 2006, A1. Location in patent: Page/Page column 32 [15] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 14, p. 4273 - 4278 [16] Synthetic Communications, 2010, vol. 40, # 19, p. 2897 - 2907 [17] Patent: WO2010/11917, 2010, A1. Location in patent: Page/Page column 59 [18] Journal of Medicinal Chemistry, 2010, vol. 53, # 21, p. 7664 - 7674 [19] Angewandte Chemie - International Edition, 2011, vol. 50, # 39, p. 9081 - 9084 [20] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3452 - 3478 [21] Journal of Medicinal Chemistry, 2012, vol. 55, # 9, p. 4189 - 4204 [22] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 12, p. 3915 - 3924 [23] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 1, p. 330 - 335 [24] ChemMedChem, 2013, vol. 8, # 3, p. 442 - 461 [25] Chemistry - A European Journal, 2014, vol. 20, # 32, p. 9902 - 9905 [26] Journal of the American Chemical Society, 2014, vol. 136, # 33, p. 11590 - 11593 [27] Chemical Communications, 2015, vol. 51, # 37, p. 7863 - 7866 [28] Journal of Organic Chemistry, 2016, vol. 81, # 5, p. 2166 - 2173 [29] Chinese Chemical Letters, 2016, vol. 27, # 9, p. 1547 - 1550 [30] Patent: CN105777580, 2016, A. Location in patent: Paragraph 0070; 0071; 0074 [31] Tetrahedron, 2017, vol. 73, # 12, p. 1576 - 1582 [32] Angewandte Chemie - International Edition, 2017, vol. 56, # 7, p. 1877 - 1880 [33] Angew. Chem., 2017, vol. 129, p. 1903 - 1906,4 [34] Angewandte Chemie - International Edition, 2017, vol. 56, # 9, p. 2482 - 2486 [35] Angew. Chem., 2017, vol. 129, # 9, p. 2522 - 2526,5 [36] Chemical Communications, 2017, vol. 53, # 33, p. 4601 - 4604 [37] Patent: CN106467537, 2017, A. Location in patent: Paragraph 0151; 0152; 0163; 0164 [38] Chemical Biology and Drug Design, 2017, vol. 90, # 2, p. 200 - 209 [39] Journal of Heterocyclic Chemistry, 2018, vol. 55, # 9, p. 2061 - 2068 [40] Chemical Communications, 2018, vol. 54, # 77, p. 10859 - 10862 [41] Patent: US5733905, 1998, A [42] Patent: US5516774, 1996, A [43] Patent: US5736540, 1998, A 路线2：
• 步骤: 在反应釜中加入邻三氟甲基苯甲酸，加入氯化亚砜，搅拌下80℃回流10h，蒸出剩余氯化亚砜，粗品减压蒸馏得成品。
• 条件: 邻三氟甲基苯甲酸、氯化亚砜、80℃回流10h
• 收率: 未明确（原始描述未提及具体收率） 路线3：
• 步骤: 在反应釜中加入邻三氟甲基苯甲酸，加入氯化亚砜，搅拌下80℃回流10h，蒸出剩余氯化亚砜，粗品减压蒸馏得成品。
• 条件: 邻三氟甲基苯甲酸、氯化亚砜、80℃回流10h
• 收率: 未明确（原始描述未提及具体收率）