2-溴-4-叔丁基苯酚主要用于医药和农药领域，具体用途需结合具体应用场景进一步研究。
医药; 农药
合成路线 1（1. 合成：2198-66-5）
产率：100%
合成条件：With bromine In tetrachloromethane; chloroform at 0℃; Inert atmosphere
实验步骤：在2小时内将溴（7.18mL，0.14mol）的氯仿（25mL）溶液滴加到4-叔丁基 - 苯酚（20g，0.133mol）在1：1v / v氯仿中的溶液中： 在氮气下，在0℃下加入四氯化碳（64mL）直至持续出现轻微的红色着色（剩余约1mL溴溶液）。 然后将反应混合物用氮气吹扫过夜。 将得到的棕褐色溶液用二氯甲烷（50mL）稀释，用1％硫代硫酸钠水溶液（100mL）和饱和盐水（100mL）洗涤，干燥（MgSO 4），过滤并减压浓缩，得到2-溴-4 - （叔丁基）苯酚（30.5g，定量收率），为无色油状物。
参考文献：
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合成路线 2（2. 合成：2198-66-5）
产率：90%
合成条件：Stage #1: With toluene-4-sulfonic acid In methanol for 0.17 h; Stage #2: With N-Bromosuccinimide In methanol for 0.42 h;
实验步骤：一般步骤：将原料（~10mmol）和pTsOH（10mol％）在MeOH（1.0mL / mmol原料）中的溶液搅拌10分钟，然后搅拌NBS溶液（100mol％;从H 2 O重结晶） 在20分钟内从箔式反应烧瓶中滴加MeOH（0.1M）的MeOH溶液。 将反应混合物再搅拌5分钟，然后真空浓缩。 使用柱色谱（CH 2 Cl 2，或在CH 2 Cl 2中的1％MeOH）纯化得到的残余物。3.3。 产物表征2-溴-4-甲基苯酚（10）[23]：10.1mmol; 1.73克（92％）;
参考文献：
- [1] Molecules, 2016, vol. 21, # 1, [2] Tetrahedron, 2009, vol. 65, # 22, p. 4429 - 4439
