6436-59-5 2-甲基噻唑-4-甲酸乙酯

运输信息：常温运输。危险描述：非危险化学品，WGK Germany:3，危险等级:IRRITANT，海关编码:29341000

化学合成。

化学合成

路线1：

• 原料：3-溴丙酮酸乙酯、硫代乙酰胺
• 溶剂：乙醇（EtOH）
• 反应条件：250 W功率、25 kHz频率、流速2 mL/min、反应时间1.5小时（感应加热）
• 产率：87.7%
• 参考文献：[1] Journal of Organic Chemistry, 1997, vol. 62, #12, p. 3804-3805；[2] Organic Letters, 2008, vol. 10, #8, p. 1565-1568；[3] Journal of Organic Chemistry, 2001, vol. 66, #19, p. 6410-6424；[4] Angewandte Chemie - International Edition, 2008, vol. 47, #46, p. 8950-8953；[5] Patent: US2010/249404, 2010, A1. Location in patent: Page/Page column 11；[6] Advanced Synthesis and Catalysis, 2014, vol. 356, #16, p. 3370-3376；[7] Tetrahedron Letters, 2016, vol. 57, #8, p. 920-923；[8] European Journal of Medicinal Chemistry, 2016, vol. 123, p. 718-726；[9] Tetrahedron Letters, 1997, vol. 38, #12, p. 2061-2064；[10] Chemistry of Heterocyclic Compounds, 2011, vol. 47, #6, p. 703-709；[11] Journal of Organic Chemistry, 2004, vol. 69, #26, p. 9269-9284；[12] Proceedings - Indian Academy of Sciences, Section A, 1945, #22, p. 362,376；[13] Journal of the Chemical Society, 1946, p. 91；[14] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, #9, p. 2243-2247；[15] Patent: WO2004/58702, 2004, A2. Location in patent: Page 29; 23；[16] Patent: WO2004/58763, 2004, A1. Location in patent: Page 38-39；[17] Patent: EP1445249, 2004, A1. Location in patent: Page 139；[18] Patent: EP1612204, 2006, A1. Location in patent: Page/Page column 47；[19] Organic Letters, 2012, vol. 14, #24, p. 6354-6357