5-溴甲基-a,a,a',a'-四甲基-1,3-二乙氰基苯（阿那曲唑EP杂质C）是阿那曲唑的杂质（杂质D）。
医药
合成路线1
- 步骤: 将3,5-双（1-氰基-1-甲基乙基）甲苯（600g，2.65mol）、N-溴代琥珀酰亚胺（519g，2.916mol）、过氧化苯甲酰（17g，0.053mol）的混合物加入四氯化碳（4.5L）中，回流反应2-2.5小时；反应完成后冷却、过滤，滤液在40-45℃浓缩至干；所得固体在75-80℃下溶于2-丙醇（2L），缓慢冷却至10-15℃搅拌1小时，进一步冷却至-5-0℃搅拌2小时，过滤，用预冷2-丙醇（200ml）洗涤滤饼，再用正己烷洗涤吸干，最后40-45℃真空干燥，得到目标产物。
- 条件: 反应溶剂为四氯化碳，反应温度为回流（约76.8℃），后处理涉及2-丙醇溶解与分步冷却结晶、正己烷洗涤、真空干燥（40-45℃）。
- 收率: 87.0%（700.2g）
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