作为医药中间体(具体用途未明确说明,基于专利文献推测用于药物合成)
医药
路线1:草酸二乙酯与乙腈为原料合成
- 原料:草酸二乙酯(5.06 g,34.62 mmol,1.00当量);叔丁醇钾(3.90 g,34.76 mmol,1.12当量);乙腈(20 mL)
- 步骤:在20 mL乙腈中溶解草酸二乙酯,于室温下分批加入叔丁醇钾;将反应混合物在室温下搅拌1.5小时
- 条件:20℃;搅拌1.5小时
- 收率:82%(5.09 g)
- 产物:黄色固体
- 参考文献:[1] Patent: US2018/162822, 2018, A1. Location in patent: Paragraph 0562;[2] Patent: US2013/225580, 2013, A1. Location in patent: Paragraph 0238; 0239;[3] Patent: US2018/9797, 2018, A1. Location in patent: Paragraph 0236; 0237;[4] Patent: WO2010/144359, 2010, A1. Location in patent: Page/Page column 84;[5] European Journal of Medicinal Chemistry, 2017, vol. 133, p. 24 - 35