5192-03-0 5-氨基吲哚

运输信息：冰袋运输。危险描述：WGK Germany:3，F:10，Hazard Note:Irritant，TSCA:TSCA listed，危险等级:AIR SENSITIVE, IRRITANT-HARMFUL, KEEP COLD，海关编码:29339990，存储类别:6.1C - 可燃，急性毒性 类别3，毒性化合物或者引起慢性影响的化合物，危险性类别:急性毒性 类别3 经皮，急性毒性 类别4 经口，危害水生环境-急性危害 类别1，眼部刺激 类别2，信号词:Warning，危险性防范说明:P261; P305 + P351 + P338，危险性描述:H302; H315; H319; H335，危险标志:GHS07。

5-氨基吲哚是一种吲哚类芳香胺，作为重要有机合成中间体和原料，广泛用于合成农药、医药、染料、表面活性剂、感光材料等方面。

医药; 农药; 染料; 表面活性剂; 感光材料

路线1：

• 步骤：向高压釜中加入4,4'-二甲氧基-2,2'-联吡啶银（0.04mmol）、叔丁醇钾（0.1mmol）、1,4-二氧六环（1mL），搅拌后加入5-硝基吲哚（1mmol），在4.0MPa氢气压力下80℃反应24小时；反应结束后用水和二氯甲烷萃取，有机相经无水Na₂SO₄干燥、抽滤、旋转蒸发、柱层析分离得到产物。
• 条件：With silver tetrafluoroborate; 4,4'-Dimethoxy-2,2'-bipyridin; potassium tert -butylate; hydrogen In 1,4-dioxane at 80℃; for 24 h; Autoclave
• 产率：98%
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路线2：

• 步骤：向烘箱干燥的烧瓶中加入芳基卤（1.0mmol）、NH₃水溶液（28％，1.5mmol）、CuI纳米颗粒（0.02mmol）、1-乙基乙酰乙酸乙酯-3-甲基咪唑鎓氢氧化物（4a，3.0mmol）和乙腈（2mL）；在氩气氛下80℃反应12小时，TLC监测反应完成后，用乙醚（5×5mL）萃取产物，有机层用盐水洗涤，经MgSO₄干燥并真空浓缩，硅胶柱层析纯化（乙酸乙酯-己烷洗脱）得到产物。
• 条件：With ammonium hydroxide; copper(I) iodide; 1-ethylacetoacetate-3-methyl imidazolium hydroxide In acetonitrile at 80℃; for 12 h; Inert atmosphere
• 产率：82%
• 参考文献：[1] Tetrahedron, 2013, vol.69, #25, p.5092-5097