生命科学领域；制备：在1000 mL三口圆底烧瓶中，依次加入L-苏氨酸45 g(0.38 mol)，无水甲醇(400mL)，冰盐浴冷却，缓慢通入干燥的氯化氢气体(自制：采用浓硫酸、浓盐酸、氯化钠制备，经浓硫酸干燥)，约4 h后固体完全消失，加热至回流反应3 h后，再次冷却，继续通入干燥氯化氢气体至饱和(称重至质量不变即为饱和)，室温反应约3 d，TLC显示反应完全后，减压蒸尽溶剂，得L-苏氨酸甲酯盐酸盐68.5g。
生命科学
合成路线 1（1. 合成：39994-75-7）
- 步骤：将L-苏氨酸溶解在甲醇HCl溶液（2M）中并将反应混合物回流1小时。然后使用旋转蒸发器蒸发有机溶剂，并将同样的甲醛HCl溶液加入到反应混合物中并回流1小时。在反应时间之后，在减压下蒸发有机溶剂，得到白色固体化合物。
- 条件：Reflux（回流）
- 收率：98%
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