没食子酸乙酯是油脂的抗氧化剂、食品添加剂及某些药品的中间体,还可作为医药中间体用于含量测定、鉴定及药理实验等;研究表明其对口腔鳞癌、肺癌、结肠癌等多种肿瘤细胞有生长抑制作用,尤其对结肠癌细胞LOVO增殖抑制最强,且通过线粒体途径诱导细胞凋亡,抑制乳腺癌侵袭转移等抗肿瘤作用。
医药; 食品添加剂; 油脂抗氧化剂
合成路线1:
- 原料:100g没食子酸、150g乙醇、35g溴化改性磺酸树脂(参照例2制备)
- 步骤:称量原料加入反应器,加热至80℃反应5小时;过滤分离滤液与树脂;蒸馏滤液除去过量乙醇得粗产物;去离子水重结晶后脱水干燥
- 条件:80℃,5小时
- 收率:98%,纯度99.9%
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