40365-61-5 2-(3-丁炔氧基)四氢-2H-吡喃

运输信息：冰袋运输。危险描述：危险品运输编号UN1993，WGK Germany 3，危险等级3，海关编码29329900，存储类别10 - 可燃性液体。危险性类别：急性毒性（经皮、吸入、经口）类别4，眼部刺激类别2，经皮刺激类别2，特异性靶器官毒性-一次接触类别3。

化学合成。

化学合成

合成路线 1（1. 合成：40365-61-5）

• 产率：98%
• 合成条件：With hydrogenchloride In water at 5 - 50℃; for 3 h;
• 实验步骤：将4-二氢-2H-吡啶（293.2g，3.5mol）和浓HCl（1.1mL）的混合物冷却至5℃。在继续外部冷却的同时，在30分钟内加入3-BUTYN-1-OL（231.5g，3.3mol），使温度达到50℃。在室温下混合保持反应2.5小时，然后用MTBE（1.0L）稀释。将所得混合物用饱和碳酸氢钠（2×150mL）洗涤。有机相用硫酸钠干燥，减压浓缩，得到500g（粗产率98％）产物; GC面积百分比为96％。
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