作为手性中间体用于医药合成，具体应用于相关药物分子的构建。
医药
路线1：以1-(8-(苄氧基)-2-羟基喹啉-5-基)-2-溴乙酮为原料合成
- 步骤: 在氮气保护下，将四氢呋喃（1400 mL）和1-(8-(苄氧基)-2-羟基喹啉-5-基)-2-溴乙酮（100 g）的混合物冷却至0-5°C；缓慢加入R-甲基CBS（7.5 g），并在0-10°C下加入硼二甲基硫醚络合物（24.3 g）；反应混合物在0-10°C下搅拌1-2小时，通过HPLC监测反应进程；反应完成后，缓慢加入甲醇（100 mL），并在0-10°C下继续搅拌15分钟；随后，在40-45°C的真空条件下蒸馏反应混合物，冷却至25-30°C；将冷却后的反应混合物缓慢加入盐酸溶液中，在25-30°C下搅拌1-2小时；过滤所得固体，用水（300 mL）洗涤，并在65-70°C下干燥8小时。
- 收率: 95%。
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