7119-95-1 1-硝基吡唑

运输方式：冰袋运输。危险性质：非危险化学品。危险等级：刺激性（IRRITANT）。WGK Germany：3。海关编码：2933199090。危险性描述：H302（吞咽有害）、H315（造成皮肤刺激）、H319（造成严重眼刺激）、H335（吸入可能导致呼吸道刺激）。信号词：Warning。危险性防范说明：P261（避免吸入粉尘/烟雾）；P305+P351+P338（眼睛接触后，立即用大量水冲洗并就医）。危险标志：GHS07。

化学合成

化学合成

合成路线 1（1. 合成：7119-95-1）

• 步骤: 将乙酸酐和发烟硝酸在体积比为5.5：1的冰水浴中缓慢混合，得到硝化剂；硝化剂和吡唑乙酸溶液分别通过高压输送到微通道反应器中，恒流泵精确控制硝酸与吡唑的摩尔比为1.1：1；45-70℃下两种液体瞬间混合反应；反应液倒入碎冰中过滤，冰水洗涤，真空干燥得到产物。
• 条件: With nitric acid; acetic anhydride In acetic acid at 55℃; Cooling with ice; Flow reactor; High pressure；温度45-70℃；流速（吡唑乙酸溶液0.1mL/min）；摩尔比1.1:1
• 产率: 92%
• 参考文献: [1] Patent: CN108570010, 2018, A. Location in patent: Paragraph 0035; 0036; 0037; 0038; 0041-0070 [2] Archiv der Pharmazie, 1995, vol. 328, # 4, p. 349 - 358 [3] ChemPlusChem, 2018, vol. 83, # 8, p. 804 - 811 [4] Journal of Chemical Research - Part S, 1996, # 5, p. 244 - 245 [5] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 1517 - 1525 [6] Chemische Berichte, 1955, vol. 88, p. 1586,1590 [7] Journal of the Chemical Society. Perkin Transactions 2, 2001, # 2, p. 197 - 200 [8] Patent: WO2006/40520, 2006, A1. Location in patent: Page/Page column 122 [9] Patent: WO2007/99326, 2007, A1. Location in patent: Page/Page column 103 [10] Patent: WO2007/99317, 2007, A1. Location in patent: Page/Page column 101 [11] Patent: WO2007/99335, 2007, A1. Location in patent: Page/Page column 94 [12] Patent: US2009/76075, 2009, A1. Location in patent: Page/Page column 36-37 [13] Chemistry - A European Journal, 2010, vol. 16, # 35, p. 10778 - 10784 [14] Journal of Molecular Structure, 2013, vol. 1043, p. 121 - 131 [15] Zeitschrift fur Anorganische und Allgemeine Chemie, 2014, vol. 640, # 11, p. 2139 - 2148 [16] Patent: CN105669557, 2016, A. Location in patent: Paragraph 0023 [17] Patent: WO2007/113548, 2007, A1. Location in patent: Page/Page column 142 [18] Patent: WO2007/113565, 2007, A1. Location in patent: Page/Page column 93