156-38-7 对羟基苯乙酸

中文名称: 对羟基苯乙酸
英文名称: 4-Hydroxyphenylacetic acid
CAS号
分子式

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名称和标识

中文名: 对羟基苯乙酸
英文名: 4-Hydroxyphenylacetic acid
CAS号: 156-38-7
分子式: C8H8O3
分子量: 152.15
中文别名: 对羟基苯醋酸; 4-羟基苯乙酸; 4-氫氧苯乙酸; 对羟苯乙酸; 4-氢氧苯乙酸; 4-羟基苯基乙酸; 4-氢氧基苯乙酸; 對羥苯乙酸; 阿替洛尔杂质F; 左甲状腺素钠杂质D
英文别名: (p-hydroxyphenyl)-aceticaci; 4-Hydroxybenzeneacetic acid; 4-Hydroxyphenylacetic acid Vetec(TM) reagent grade; Arbidol Impurity F HCl; Levothyroxine Sodium Impurity d; NSC 27460; Acetic acid, (p-hydroxyphenyl)-; ethanoicacid,4-hydroxyphenyl-; 2-(4-hydroxyphenyl)acetic acid; p-hydroxyphenylacetic acid; (4-Hydroxyphenyl)acetic acid; benzeneacetic acid, 4-hydroxy-; 4-Carboxymethylphenol; Parahydroxy phenylacetic acid; NSC-25066; DTXSID5059745; CHEBI:18101; para-hydroxyphenylacetic acid; Hydroxyphenylacetic acid; MFCD00004347; EINECS 205-851-3; p-hydroxyphenylacetate; p-Hydroxyphenyl acetic acid; Parahydroxy phenylacetate; 4-hydroxyphenyl-acetic acid; CHEMBL1772; 4-Hydroxy-Benzeneacetic acid; (4-hydroxy-phenyl)-acetic acid; 4-hydroxybenzeneacetate; 4HP; (p-hydroxyphenyl)acetate; 2-[4-(hydroxy)phenyl)acetic acid; 4-HPA; 2-(4-(HYDROXY)PHENYL)ACETIC ACID; 4-(Carboxymethyl)phenol; UNII-3J9SHG0RCN; NSC 25066; BRN 1448766; 4-hydroxy phenyl acetic acid; AI3-17755; 3pcg; Parahydroxyphenylacetate; 1ai6; 4-Hydroxy-Benzeneacetate; 4-hydroxyphenyacetic acid; 4-hydroxyphenylactic acid; 4-hyroxyphenylacetic acid; (p-hydroxyphenyl)-Acetate; ChemDiv3_005483; 4-hydroxylphenylacetic acid; bmse000455; 4- hydroxyphenylacetic acid; 4-hydroxy-phenylacetic acid; 4-hydroxyphenylethanoic acid; p-hydroxy benzeneacetic acid; (4-hydroxy-phenyl)-acetate; p-hydroxy phenyl acetic acid; 4-Hydroxybenzene acetic acid; SCHEMBL75700; 4-hydroxy-phenyl acetic acid; 4-10-00-00543 (Beilstein Handbook Reference); MLS001066398; (p-hydroxyphenyl)-Acetic acid; (4-hydroxyphenyl) acetic acid; (4-hydroxyphenyl)-acetic acid; (4-hydroxyphenyl)ethanoic acid; Acetic acid, 4-hydroxyphenyl-; orb1303813; orb3025993; SCHEMBL7191616; (4-Hydroxy-phenyl)-essigsaeure; SCHEMBL10460348; SCHEMBL10626583; SCHEMBL17028326; HY-N1902R; 4-Hydroxyphenyl acetic acid; PHPA

物化属性

LogP: 0.75 at 25℃
XLogP3: 0.8
pH值: 2.0-2.4 (30g/L, H2O, 20℃)
储存条件: 储存于密封的惰性气氛中，放置在阴凉干爽位置
分子量: 152.15 g/mol
可旋转键数量

安全信息

安全说明

常温运输，该物质为可燃固体，具有刺激性：可造成皮肤刺激、严重眼刺激，可能造成呼吸道刺激；WGK德国为3类，RTECS号为AI2680000，海关编码29182990，存储类别为11类。

生产及用途

用途与制备

用作医药原料，用于制备头孢菌系抗生素、解热镇痛药、β-受体阻滞药阿替洛尔等；用作农药原料，用于制备菊酯类杀虫剂；用作有机合成中间体，可合成4,7-二羟基异黄酮、3,4-二羟基苯乙酸等；还可用作测定氧化酶的荧光试剂、酚类与胺类化合物的酰化反应试剂。

医药; 农药; 有机合成; 分析试剂

路线1：重氮化水解法

步骤：将对氨基苯乙酸与碱溶液配制成钠盐，再加入硫酸；冷至0℃，控制温度在0-5℃滴加硝酸钠溶液，加毕反应0.5h；将所得重氮液滴加至90-95℃的稀硫酸中，约1h滴完，继续反应1h；反应液经脱色过滤，冷却后用乙酸乙酯提取，回收乙酸乙酯得成品。
收率：约85%