34107-46-5 6-甲基-3-羟甲基吡啶

运输信息：常温运输。危险描述：WGK Germany:3；危险等级：刺激性；海关编码：2933399990；存储类别：11 - 可燃固体；危险性类别：急性毒性 类别4（经口）、严重眼损伤 类别1、经皮刺激 类别2、特异性靶器官毒性 - 一次接触 类别3；信号词：危险；防范说明：P261、P280、P305+P351+P338；危险描述：H302、H315、H318、H335；危险标志：GHS05、GHS07。非危险化学品。

主要用于化学合成领域，作为中间体或原料参与相关化学反应。

化学合成

合成路线1

• 原料：化合物11（或6-甲基烟酸甲酯，21g；140mmol；1当量）
• 试剂：1M LiAlH₄的THF溶液（210mL；210mmol；1.5当量）
• 步骤：在-5℃下，向搅拌的化合物11（或6-甲基烟酸甲酯）的无水THF（150mL）溶液中滴加1M LiAlH₄的THF溶液；滴加完毕后，在23℃下继续搅拌2小时；随后冷却至-10℃，用硫酸钠十水合物和乙酸乙酯淬灭反应直至停止冒泡；过滤，滤液减压浓缩至干，得到产物。
• 收率：100%（17g）
• 表征：¹H NMR（DMSO-d₆）δ 8.37（s，1H），7.59（dd，1H，J=2,8Hz），7.19（d，1H，J=8Hz），5.22（t，1H，J=6Hz），4.47（d，2H，J=6Hz），2.45（s，3H）
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