化学合成
化学合成
合成路线：以7-溴-1H-苯并[d]-1,3-恶嗪-2,4-二酮为原料
- 步骤：在室温下将205.0g（0.84mol）7-溴-1H-苯并[d]-1,3-恶嗪-2,4-二酮悬浮于1.26L（12.59mol）磷酰氯中，加入71.34mL（0.42mol）N-乙基二异丙胺，加热回流36小时
- 产率：79%
- 产物表征：HPLC/MS（M+H）+ = 277/279，为固体
- 参考文献：[1] Patent: US2013/12489, 2013, A1. Location in patent: Paragraph 0174；[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, #21, p. 4904-4907；[3] Patent: WO2012/58671, 2012, A1. Location in patent: Page/Page column 92-93；[4] Patent: US2014/38952, 2014, A1. Location in patent: Page/Page column 0160-0161；[5] Antimicrobial Agents and Chemotherapy, 2017, vol. 61, #6
