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杂环化合物

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(2R,3R)-3-((S)-1-(叔丁氧基羰基)吡咯烷-2-基)-3-甲氧基-2-甲基丙酸
英文名称
(2R,3R)-3-((S)-1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid
CAS号
120205-50-7
分子式
C₁₄H₂₅NO₅
分子量
287.35
中文别名
海兔毒素中间体; 利妥昔单抗中间体1; 海兔毒素中间体1; ((2R,3R)-3-((S)-1-(TERT丁氧基羰基)吡咯烷-2-基)-3-甲氧基-2-甲基丙酸; ((2R,3R)-3-((S)-1-(叔丁氧基羰基)吡咯烷-2-基)-3-甲氧基-2-甲基丙酸; (ALPHAR,BETAR,2S)-1-[叔丁氧羰基]-BETA-甲氧基-ALPHA-甲基-2-吡咯烷丙酸; N-Boc-(2R,3R,4S)-dolaproine; Dolproline; N-Boc-dolaproline; (2R,3R)-BOC-dolaproine; N-Boc-dolaproine; (2R,3R)-3-Methoxy-2-Methylpropanoic acid (DAP); N-Boc-dolaproline acid; (2R,3R)-3-methoxy-2-methyl-3-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]propanoic acid; (2R,3R)-3-Methoxy-2-methyl-3-[(2S)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-2-pyrrolidinyl]propanoic acid; ((2R,3R)-3-((S)-1-(tertbutoxycarbonyl)pyrrolidin-2-yl)-3-Methoxy-2-Methylpropanoic acid
用途
海兔毒素海兔是雌雄同体的生物，海底栖息，体裸露，雌雄两个生殖孔间有卵精沟相连。这种神奇的动物目前已知的有大约3000多种，分布于全球各个海域。科学家从海兔体内提取出一种“海兔毒素”，通过动物实验，认为可作为抗癌剂。这种制剂只对癌细胞起杀灭作用，对正常细胞无毒性，海兔抗癌制剂的出现，使海兔声名远扬。海兔毒素的由来：海洋生物毒素之一，发现自食藻软体动物长尾背肛海兔的消化腺，因此命名为海兔毒素。为线性缩肽类天然细胞毒性蛋白，在生物体中含量极少。具有高抗癌作用。海兔毒素结构：它是一种九肽，在生物体中含量极少。至今已鉴定出18个含有特殊氨基酸的较短链状肽类化合物，命名为dolastatin1～18。其中Dolastatin3，Dolastatin10（D10），Dolastatin15的结构被确定。而D10是研究最多的一种，一般都以D10作为海兔毒素的代表。 Dolastatin10的介绍：D10是由4个氨基酸组成的线性缩肽类天然细胞毒性蛋白，含有9个不对称碳原子，从氨基端开始依次是dolavaline（Dov）、valine、dolaisoleuine（Dil）、dolaproine（Dap）4种氨基酸及特异的可能从苯丙氨酸分离出来的伯胺dolaphenie（Doe）作为羧基端缩合而成，故有研究者称其为5肽产物，相对分子质量为784。D10有一系列同分异构体，其中一些具有生物效应。天然的D-10产量极小，而现有的合成方法和路线仅限于实验室规模，无法满足日益增长的需求。其根本原因在于无法高效立体选择合成D-10中最复杂的组分，即具有三个手性中心的Dolaproine（Dap）。
相关属性
基本信息物化属性
(2R,3R,4R)-2-(羟甲基)哌啶-3,4-二醇
英文名称
fagomine
CAS号
53185-12-9
分子式
C₆H₁₃NO₃
分子量
147.17
中文别名
荞麦碱; 桑叶生物碱; 乔麦碱; 法古米; (2R)-2-(Hydroxymethyl)piperidine-3β,4α-diol; (2R)-2α-(Hydroxymethyl)piperidine-3β,4α-diol; (2R)-3β,4α-Dihydroxypiperidine-2α-methanol; 1,2,5-Trideoxy-1,5-epimino-D-xylo-hexitol; (2R,3R,4R)-3,4-Dihydroxy-2-piperidinemethanol; (2R,3R,4R)-2-(Hydroxymethyl)piperidine-3,4-diol; D-FagoMine; 1,5-imino-1,2,5-trideoxy-D-arabino hexitol; 1,2,5-Trideoxy-1,5-imino-D-arabino-hexitol; (2R,3R,4R)-2-(Hydroxymethyl)-3,4-piperidinediol
用途
生命科学，是一种温和的糖苷酶 (glycosidase) 抑制剂；中草药成分。
相关属性
基本信息物化属性
(2R,3R,4R,5S)-1-丁基-2-(羟甲基)哌啶-3,4,5-三醇盐酸盐
英文名称
N-Butyldeoxynojirimycin Hydrochloride
CAS号
210110-90-0
分子式
C₁₀H₂₂ClNO₄
分子量
255.74
中文别名
Miglustat盐酸盐; N-(正丁基)-1-脱氧野尻霉素盐酸盐; N-丁基脱氧野尻霉素盐酸盐; 米格鲁特盐酸盐; 盐酸美格鲁特; N-(正丁基)-1-脱氧诺吉霉素盐酸盐; (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride; Miglustat hydrochloride; Miglustat (hydrochloride); Hydrogen chloride (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol (1:1:1); 3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, chloride, hydrogen salt, (2R,3R,4R,5S)- (1:1); (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriolhydrochloride; N-Butyldeoxynojirimycin hydrochloride; N-Butyldeoxynojirimycin.HCl; Miglustat HCl; NB-DNJ hydrochloride; OGT918 hydrochloride; N-Butyl-DNJ, HCL; N-BUTYLDEOXYNOJIRIMYCIN HCL; N-(N-BUTYL)DEOXYNOJIRIMYCIN, HYDROCHLORIDE
用途
Miglustat hydrochloride 是一种葡萄糖神经酰胺合成酶抑制剂，可作用于 I 型戈谢病。
相关属性
基本信息物化属性
(2R,3R,4R,5S)-2-(羟甲基)-1-壬基哌啶-3,4,5-三醇
英文名称
N-Nonyldeoxynojirimycin
CAS号
81117-35-3
分子式
C₁₅H₃₁NO₄
分子量
289.41
中文别名
N-Nonyldeoxynojirimycin; N-(n-Nonyl)deoxynojirimycin; N-(正壬基)-1-脱氧野尻霉素; N-(N-壬基)-1-脱氧诺吉霉素; N-(正壬基)脱氧野尻霉素; NN-DNJ; NONYL-DNJ; (2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonylpiperidine-3,4,5-triol; NN-DNJ; N-Nonyl-deoxynojirimycin; N-nonyl-1-deoxynojirimycin; N-Nonyl-DNJ; N-(N-NONYL)DEOXYNOJIRIMYCIN; (2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol; N-(n-Nonyl)-1-deoxynojirimycin; Nonyl-DNJ; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-nonyl-, (2R,3R,4R,5S)-
用途
作为有效的α-葡萄糖苷酶和α-1,6-葡萄糖苷酶抑制剂，IC50值分别为0.42μM和8.4μM，可抑制糖原的降解
相关属性
基本信息物化属性
(2R,3S,4R,5S)-1-丁基-2-(羟基甲基)哌啶-3,4,5-三醇
英文名称
Lucerastat
CAS号
141206-42-0
分子式
C₁₀H₂₁NO₄
分子量
219.28
中文别名
N-(正丁基)脱氧半乳糖苷嘧啶; N-(正丁基)脱氧半乳糖霉素; 芦舍司他; N-(n-丁基)脱氧半乳糖野尻霉素; 化合物T32923; 米加司他杂质1; 化合物LUCERASTAT; N-(n-Butyl)deoxygalactonojirimycin; NB-DGJ; N-Butyl-DGJ; N-Bu-DGJ; ACT-434964; lucerastatum; N-Butyldeoxygalactonojirimycin; N-Butyl-1-deoxygalactonojirimycin; NBDGJ; N-Butyl-1,5-dideoxy-1,5-imino-D-galactitol; N-n-Butyldeoxygalactonojirimycin; N-Butyl-D-galacto-1-deoxynojirimycin; OGT-923; CDP-923
用途
化学合成；作为葡萄糖酰神经酰胺合成酶(GCS)抑制剂，在Fabry疾病研究中具有潜在应用。体外实验中，对携带R301G、R220X和W162X基因型的Fabry患者成纤维细胞进行细胞活力检测，显示其剂量依赖性抑制GCS，减少葡萄糖神经酰胺并增加神经酰胺。体内实验中，以1200 mg/kg/day食物混合剂形式给药，在Fabry小鼠模型中，20周后显著降低肾脏Gb3(-33%, p<0.01)、背根神经节α-半乳糖基终止糖鞘脂(-48%, p<0.05)及肝脏中葡萄糖神经酰胺和Gb3含量。
相关属性
基本信息物化属性
(2R,3S,4R,5S)-2-(羟甲基)哌啶-3,4,5-三醇盐酸盐
英文名称
Migalastat hydrochloride
CAS号
75172-81-5
分子式
C₆H₁₄ClNO₄
分子量
199.63
中文别名
脱氧半乳糖野生霉素盐酸盐; 1-脱氧半乳糖野尻霉素盐酸盐; 脱氧半乳糖诺吉霉素; 1-脱氧半乳糖诺吉霉素盐酸盐; (2R,3S,4R,5S)-2-甲醇哌啶-3,4,5-三醇盐酸盐; (2R,3S,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol hydrochloride; deoxygalactonojirimycin, hydrochloride; Deoxygalactonojirimycin Hydrochloride; (1R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidinium chloride; 1,5-dideoxy-1,5-imino-D-glucitol hydrochloride; 1-Deoxymannojirimycinehydrochloride; DEOXYMANNONOJIRIMYCIN HCL; (+)-(2R,3R,4R,5S)-2-hydroxymethyl-3,4,5-trihydroxypiperidine hydrochloride; DEOXYMANNOJIRIMYCIN,HYDROCHLORIDE; (+)-1-deoxynojirimycin hydrochloride; 1-DEOXYMANNOJIRIMYCIN HCL; DMM; DMJ,HYDROCHLORIDE; Migalastat (hydrochloride); 1,5-DIDEOXY-1,5-IMINO-D-GALACTITOL, HYDROCHLORIDE; 1-DEOXYGALACTONOJIRIMYCIN HCL; DGJ; DGJ, HYDROCHLORIDE; GALACTOSTATIN HCL; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, hydrochloride, (2R,3S,4R,5S)-
用途
作为有效和竞争性的α-galactosidase A抑制剂，对人α-Gal A的IC50值为0.04 μM；在转基因小鼠中，经其处理后，心脏、肾脏、脾脏和肝脏中的α-Gal A活性呈剂量和时间依赖性增加；口服给药可降低法布里转基因小鼠的组织GL-3水平，以及部分法布里病患者尿液和肾脏中的GL-3水平；还可降低转基因小鼠肾脏、心脏和皮肤中升高的lyso-Gb3水平，分别高达64%、59%和81%
相关属性
基本信息物化属性
(2R,4R)-1-(叔丁氧基羰基)-4-苯基吡咯烷-2-羧酸
英文名称
(2R,4R)-1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-2-carboxylic acid
CAS号
158567-91-0
分子式
C₁₆H₂₁NO₄
分子量
291.34
中文别名
(2R,4R)-Boc-4-苯基吡咯烷-2-羧酸; (2R-反式)-4-苯基-1,2-吡咯烷二羧酸 1-叔丁酯; (2R,4R)-1-BOC-4-苯基吡咯烷-2-甲酸; (2R,4R)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-phenylpyrrolidine-2-carboxylic acid; (2R,4R)-Boc-4-phenyl-pyrrolidine-2-carboxylic acid; (2R,4R)-1-tert-butoxycarbonyl-4-phenyl-pyrrolidine-2-carboxylic acid; (2R,4R)-1-(BOC)-4-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID; (2R,4R)-1-Boc-4-phenylpyrrolidine-2-carboxylic Acid; (4R)-1-(tert-Butoxycarbonyl)-4-phenyl-D-proline; (2R-trans)-4-Phenyl-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester; 1,2-Pyrrolidinedicarboxylic acid, 4-phenyl-, 1-(1,1-dimethylethyl) ester, (2R-trans)- (9CI); Boc-(2R,4R)-4-phenyl-pyrrolidine-2-carboxylic acid; (2R,4R)-Boc-4-phenylpyrolidine-2-carboxylic acid; (4R)-1-Boc-4-phenyl-D-proline
用途
化学合成。
相关属性
基本信息物化属性
(2R,4R)-1-(叔丁氧羰基)-4-羟基吡咯烷-2-羧酸
英文名称
(2R,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
CAS号
135042-12-5
分子式
C₁₀H₁₇NO₅
分子量
231.25
中文别名
N-Boc-顺式-4-羟基-D-脯氨酸; (2R,4R)-N-叔丁氧羰基-4-羟基吡咯烷-2-甲酸; 顺式-N-BOC-4-羟基-D-脯氨酸; BOC-D-顺式-HYP-OH; 正-BOC-顺式-4-羟基-D-脯氨; 正-Boc-顺式-4-羟基-D-脯氨酸; Boc-顺式-4-羟基-D-脯氨酸; (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid; Boc-Cis-4-Hydroxy-D-Proline; (2R,4R)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID; BOC-(2R,4R)-(+)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID; BOC-D-CISHYP-OH; N-T-BOC-CIS-4-HYDROXY-D-PROLINE; N-BOC-CIS-4-HYDROXY-D-PROLINE; N-ALPHA-BUTOXYCARBONYL-CIS-4-HYDROXY-D-PROLINE; (4S)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline; (4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline; (2R,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid; (2R,4R)-N-Boc-4-hydroxy-2-pyrrolidinecarboxylic acid
用途
N-Boc-顺式-4-羟基-D-脯氨酸主要用作有机合成和医药化学中间体，用于生物活性分子和多肽类药物分子的合成。在有机合成转化中，N-Boc-顺式-4-羟基-D-脯氨酸中的羧基可以在硼烷的作用下被还原成羟基基团，此外羧基还可以和醇类化合物进行缩合反应生成相应的酯类产物。
相关属性
基本信息物化属性
(2R,4R)-4-氨基-2-甲基吡咯烷-1-羧酸叔丁酯
英文名称
(2R,4R)-tert-Butyl 4-amino-2-methylpyrrolidine-1-carboxylate
CAS号
348165-63-9
分子式
C₁₀H₂₀N₂O₂
分子量
200.28
中文别名
4-氨基-2-甲基-1-吡咯烷羧酸-1,1-二甲基乙酯, (2r,4r)- (9ci); 4-氨基-2-甲基-1-(2R,4R)-吡咯烷羧酸叔丁酯; BOC-4-氨基-2-甲基-1-(2R,4R)-吡咯烷; 叔-丁基 (2R,4R)-4-氨基-2-甲基吡咯烷-1-甲酸基酯; (2R,4R)-叔丁基4-氨基-2-甲基吡咯烷-1-羧酸酯; (3R,5R)-1-BOC-5-甲基吡咯烷-3-胺; tert-Butyl (2R,4R)-4-amino-2-methylpyrrolidine-1-carboxylate; 2-Methyl-2-propanyl (2R,4R)-4-amino-2-methyl-1-pyrrolidinecarboxylate; 1-Pyrrolidinecarboxylicacid,4-amino-2-methyl-,1,1-dimethylethylester,(2R,4R)-(9CI); 1,1-Dimethylethyl 4-amino-2-methyl-1-(2R,4R)-pyrrolidinecarboxylate; (2R,4R)-4-Amino-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester
用途
化学合成。
相关属性
基本信息物化属性
(2R,4R)-4-甲基-2-哌啶甲酸
英文名称
(2R,4R)-4-Methylpiperidine-2-carboxylic acid
CAS号
74892-81-2
分子式
C₇H₁₃NO₂
分子量
143.18
中文别名
阿加曲班杂质35; (2R,4R)-4-甲基六氢吡啶-2-羧酸; 阿加曲班杂质E; 阿加曲班-1; (2R,4R)-4-甲基哌啶-2-甲酸; (2R,4R)-4-甲基哌啶-2-羧酸; 阿加曲班中间体7; Argatroban Impurity 35; (2R,4R)-4-METHYLPIPERIDINE-2-CARBOXYLIC ACID; (2R,4R)-4-Methylpipecolinic acid; 2-Piperidinecarboxylic acid, 4-methyl-, (2R,4R)-; Argatroban Impurity 132; (2R,4R)-4-Methyl-2-piperidinecarboxylate; ARGATROBAN INTER-1; (2R,4R)-4-methylpiperidinecarboxylic acid; (2R,4R)-4-methyl-2-piperidinecarboxylic acid; (2R,4R)-4-methylpipecolic acid; (2R-trans)-4-Methyl-2-piperidinecarboxylic acid; 2-piperidinecarboxylic acid,4-methyl-,(2r,4r); (2r,4r)-4-methyl-2-pipecolic acid
用途
化学合成。
相关属性
基本信息物化属性
(2R,4R)-4-羟基吡咯烷-2-羧酸甲酯盐酸盐
英文名称
(2R,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride
CAS号
114676-59-4
分子式
C₆H₁₂ClNO₃
分子量
181.62
中文别名
(2R,4R)-4-羟基吡咯烷-2-甲酸甲酯盐酸盐; (2R,4R)-顺式-4-羟基-D-脯氨酸甲酯盐酸盐; (4R)-4-羟基-D-脯氨酸甲酯盐酸盐; 甲基 (2R,4R)-4-羟基吡咯烷-2-甲酸基酯盐酸盐; 顺式-4-羟基-D-脯氨酸甲酯盐酸盐; D-Proline, 4-hydroxy-, methyl ester (hydrochloride); D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-; Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride; (2R,4R)-4-Hydroxy-2-(methoxycarbonyl)pyrrolidine hydrochloride; cis-4-Hydroxy-D-proline methyl ester hydrochloride; Methyl 4-hydroxypyrrolidine-2-carboxylate HCl; Cis-4-Hydroxy-D-proline Methyl ester HCl; (2R,4R)-cis-4-hydroxy-D-proline methyl ester hydrochloride; Cis-D-Hyp-OMe.HCl; D-Proline, 4-hydroxy-, methyl ester, (Hydrochloride) (1:1), (4R); D-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1); Methyl (4R)-4-hydroxy-D-prolinate hydrochloride (1:1); (2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid methyl ester hydrochloride
用途
化学合成。
相关属性
基本信息物化属性
(2R,4R)-4-羟基吡咯烷-2-羧酸甲酯盐酸盐
英文名称
Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride
CAS号
114676-59-4
分子式
C₆H₁₁NO₃.ClH
分子量
181.62
中文别名
(2R,4R)-4-羟基吡咯烷-2-甲酸甲酯盐酸盐; (2R,4R)-顺式-4-羟基-D-脯氨酸甲酯盐酸盐; (4R)-4-羟基-D-脯氨酸甲酯盐酸盐; 甲基 (2R,4R)-4-羟基吡咯烷-2-甲酸基酯盐酸; cis-4-Hydroxy-D-proline methyl ester hydrochloride; Methyl 4-hydroxypyrrolidine-2-carboxylate HCl; Cis-4-Hydroxy-D-proline Methyl ester HCl; (2R,4R)-4-Hydroxy-2-(methoxycarbonyl)pyrrolidine hydrochloride; Cis-D-Hyp-OMe.HCl; D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-
用途
概述 (2R,4R)-4-羟基吡咯烷-2-羧酸甲酯盐酸盐是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联活性分子 (ADCs)。D-Proline, 4-hydroxy-, methyl ester (hydrochloride) 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。
相关属性
基本信息物化属性
(2R,4R)-N-Boc-4-羟基-2-甲基吡咯烷
英文名称
(2R,4R)-tert-Butyl 4-hydroxy-2-methylpyrrolidine-1-carboxylate
CAS号
114676-93-6
分子式
C₁₀H₁₉NO₃
分子量
201.26
中文别名
(2R,4R)-4-羟基-2-甲基吡咯烷-1-甲酸叔丁酯; (2R,4R)-N-BOC-2-甲基-4-羟基-吡咯烷; 叔-丁基 (2R,4R)-4-羟基-2-甲基吡咯烷-1-甲酸基酯; (2R,4R)-1-BOC-2-甲基-4-羟基吡咯烷; tert-Butyl (2R,4R)-4-hydroxy-2-methylpyrrolidine-1-carboxylate; (2R,4R)-N-Boc-4-hydroxy-2-methylpyrrolidine; 2-Methyl-2-propanyl (2R,4R)-4-hydroxy-2-methyl-1-pyrrolidinecarboxylate; (2R,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-methylpyrrolidine; (2R,4R)-4-Hydroxy-2-methyl-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester; (2R, 4R)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester; 1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-methyl-, 1,1-dimethylethyl ester, (2R,4R)-; (2R,4R)-N-Boc-2-methyl-4-hydroxy-prrolidine
用途
化学合成。
相关属性
基本信息物化属性
(2R,4S)-4-氟吡咯烷-2-羧酸
英文名称
(2R,4S)-4-Fluoropyrrolidine-2-carboxylic acid
CAS号
131176-02-8
分子式
C₅H₈FNO₂
分子量
133.12
中文别名
(2R,4S)-4-氟吡咯烷-2-甲酸; (2R,4S)-顺式-4-氟-L-脯氨酸; trans-4-Fluoro-D-proline; (2S,4R)-4-fluoroproline; (4R)-4-fluoroproline; (2S,4R)-4-fluoro-pyrrolidine-2-carboxylic acid; 4-Fluoro-pyrrolidine-2-carboxylic acid; D-Proline,4-fluoro-,(4S); (2R,4S)-4-Fluoro-2-pyrrolidinecarboxylic acid; (2R,4S)-4-fluoropyrrolidinium-2-carboxylate; (4S)-4-Fluoro-D-proline; (2R,4S)-4-fluoro-2-proline; D-Proline, 4-fluoro-, (4S)-; (2R,4S)-4-fluoropyrrolidin-1-ium-2-carboxylate; D-Proline, 4-fluoro-, trans-; (2R,4S)-4-fluoropyrrolidine-2-carboxylicacid; (2R4S)-4-fluoropyrrolidine-2-carboxylic acid; (2R-trans)-4-fluoro-2-pyrrolidinecarboxylic acid
用途
化学合成；生命科学。
相关属性
基本信息物化属性
(2R,4S)-4-羟基-2-(羟甲基)-1-吡咯烷羧酸叔丁酯
英文名称
tert-butyl (2R,4S)-4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate
CAS号
77450-03-4
分子式
C₁₀H₁₉NO₄
分子量
217.26
中文别名
(2R,4S)-4-羟基-2-(羟基甲基)吡咯烷-1-羧酸叔丁酯; N-BOC-反式羟基脯氨醇; (2R,4S)-N-BOC-2-羟甲基-4-羟基-吡咯烷; (3S,5R)-1-BOC-5-(羟甲基)吡咯烷-3-醇; (2R,4S)-tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate; (2R,4S)-N-Boc-4-hydroxyprolinol; (2R,4S)-4-Hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid tert-butyl ester; N-(tert-Butoxycarbonyl)-4-hydroxy-D-prolinol; trans-4-Hydroxy-L-prolinol,N-BOC protected; N-(tert-butoxycarbonyl)-trans-4-hydroxy-D-prolinol; (2S,4R)-tert-butyl4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate; (2R,4S)-4-hydroxyprolinol-1-carboxylic acid tert-butyl ester; 1-N-BOC-(2R,4S)-4-HYDROXY-2-(HYDROXYMETHYL) PYRROLIDINE; 1-Pyrrolidinecarboxylicacid,4-hydroxy-2-(hydroxymethyl)-,1,1-dimethylethylester,(2R,4S); 2-Methyl-2-propanyl (2R,4S)-4-hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylate; (4S)-1-Boc-4-hydroxy-D-prolinol
用途

相关属性
基本信息物化属性
(2R,4S)-4-羟基吡咯烷-2-羧酸甲酯盐酸盐
英文名称
(2R,4S)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride
CAS号
481704-21-6
分子式
C₆H₁₂ClNO₃
分子量
181.62
中文别名
反式4羟基D脯胺酸甲酯盐酸盐; (4S)-4-羟基-D-脯氨酸甲酯盐酸盐; (S)-4-羟基-D-脯氨酸甲酯盐酸盐; (2R,4S)-4-羟基吡咯烷-2-甲酸甲酯盐酸盐; 反式-4-羟基-D-脯氨酸甲酯盐酸盐; 反式-4-羟基-D-脯胺酸甲酯盐酸盐; 反式-4-羟基-L-脯氨酸甲酯盐酸盐; (2S,4R)-甲基 4-羟基吡咯烷-2-羧酸盐酸盐; (2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride; (4S)-4-Hydroxy-D-proline Methyl ester hydrochloride; (4S)-D-Proline-4-hydroxyMethylester hydrochloride; (S)-4-Hydroxy-D-proline Methyl Ester Hydrochloride; Methyl (2R,4S)-4-hydroxypyrrolidine-2-carboxylate hydrochloride; D-Proline-4-hydroxyMethylester hydrochloride (4S); trans-4-Hydroxy-D-proline methyl ester hydrochloride, (2R,4S)-4-Hydroxy-2-(methoxycarbonyl)pyrrolidine hydrochloride; D-Proline, 4-hydroxy-, Methyl ester, hydrochloride (1:1), (4S)-; Trans-4-hydroxy-L-proline methyl ester hydrochloride; L-hydroxyproline methyl ester hydrochloride; L-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1); 4S-hydroxy-1-pyrrolidine-2R-carboxylic acid methyl ester hydrochloride salt
用途
化学合成；作为不可降解ADC linker用于合成抗体偶联活性分子(ADCs)；作为基于烷基链的PROTAC linker用于合成PROTAC。
相关属性
基本信息物化属性
(2R,5R)-2,5-二甲基-1-哌嗪甲酸叔丁酯
英文名称
tert-butyl (2R,5R)-2,5-dimethylpiperazine-1-carboxylate
CAS号
1240586-48-4
分子式
C₁₁H₂₂N₂O₂
分子量
214.3
中文别名
(2R,5R)-叔-丁基 2,5-二甲基哌嗪-1-羧酸酯; (2R,5R)-1-BOC-2,5-二甲基哌嗪; 1-Piperazinecarboxylic acid, 2,5-diMethyl-, 1,1-diMethylethyl ester, (2R,5R)-; (2R,5R)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER; (2R,5R)-tert-Butyl 2,5-diMethylpiperazine-1-carboxylate; (2R,5R)-2,5-Dimethyl-1-piperazinecarboxylic acid tert-butyl ester; (2R,5R)-1-Boc-2,5-dimethylpiperazine; (2R,5R)-N-Boc-2,5-dimethylpiperazine; 2-Methyl-2-propanyl (2R,5R)-2,5-dimethyl-1-piperazinecarboxylate
用途
化学合成，医药中间体。
相关属性
基本信息物化属性
(2R,5R)-2,5-二甲基吡咯烷
英文名称
(2R,5R)-2,5-Dimethylpyrrolidine
CAS号
62617-70-3
分子式
C₆H₁₃N
分子量
99.17
中文别名
(2R,5R)-(-)-反-2,5-二甲基吡咯烷; (2R,5r)-(-)-反式-2,5-二甲基吡咯烷; trans-2,5-dimethylpyrrolidine; Pyrrolidine, 2,5-dimethyl-, (2R,5R)-; (2R,5R)-(-)-TRANS-2,5-DIMETHYLPYRROLIDINE
用途

相关属性
基本信息物化属性
(2R,5R)-2,5-二苯基吡咯烷
英文名称
(2R,5R)-2,5-diphenylpyrrolidine
CAS号
155155-73-0
分子式
C₁₆H₁₇N
分子量
223.31
中文别名
(2R,5R)-二苯基吡咯烷; (R,R)-2,5-二苯基吡咯烷; (+)-(R,R)-2,5-diphenylpyrrolidine; (R,R)-trans-2,5-diphenylpyrrolidine; (2R,5R)-Diphenylpyrrolidine; (+)-trans-2,5-diphenylpyrrolidine; (2R,5R)-(+)-2,5-diphenylpyrrolidine; (2R,5R)-2,5-diphenylprrolidine; (R,R)-2,5-Diphenylpyrrolidine; Pyrrolidine,2,5-diphenyl-, (2R,5R)-; rel-(2R,5R)-2,5-Diphenylpyrrolidine
用途

相关属性
基本信息物化属性
(2R,5R)-2,5-双(甲氧基甲基)吡咯烷
英文名称
(2R,5R)-2,5-Bis(methoxymethyl)pyrrolidine
CAS号
90290-05-4
分子式
C₈H₁₇NO₂
分子量
159.23
中文别名
(R,R)-(-)-2,5-二(甲氧甲基)吡咯烷; (R,R)-(-)-2,5-二(甲氧基甲基)吡咯烷; (R,R)-(-)-2,5-双(甲氧基甲基)吡咯烷; 米洛巴林杂质28; 米洛巴林杂质37; 米洛巴林杂质30; (R,R)-(-)-2,5-Bis(methoxymethyl)pyrrolidine; (r,r)-(-)-2,5-bis(methoxymethyl)-pyrrolidine; (2R,5R)-2,5-dimethoxymethylpyrrolidine; (-)-2,3,4,5-Tetradeoxy-2,5-imino-1-O,6-O-dimethyl-L-threo-hexitol; (R,R)-2,5-bis(methoxymethyl)pyrrolidine; (2R,5R)-bis(methoxymethyl)pyrrolidine; (R,R)-2,5-di-(methoxymethyl)pyrrolidine; [2R,5R,(-)]-2,5-Bis(methoxymethyl)pyrrolidine; (2R)-2β,5α-Bis(methoxymethyl)pyrrolidine; 2β,5α-Bis(methoxymethyl)pyrrolidine; Pyrrolidine, 2,5-bis(methoxymethyl)-, (2R,5R)-
用途
化学合成。
相关属性
基本信息物化属性